Isoindolinone structure is an important privileged scaffold found in a large variety of naturally
occurring as well as synthetic, biologically and pharmaceutically active compounds. Owing …

As important reactive species, isoindolinones represent a cluster of valuable building blocks
for the construction of natural‐product‐like compounds. In particular, chiral isoindolinones …

Asymmetric Synthesis of 3-Substituted Isoindolinones: Application to the Total Synthesis of (+)-Lennoxamine
| Organic Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic …

The transition-metal-catalyzed enantioselective alkylation and arylation of imines is a
versatile means of accessing α-chiral amines, which are important structural components of …

An unprecedented CuI–pybox‐diPh‐catalyzed highly enantioselective (up to> 99% ee)
alkynylation/lactamization cascade has been developed as a general catalytic system for the …

Main observation and conclusion Herein, we report an efficient, tunable system for
electrochemical reduction of ketones and phthalimides at room temperature without the …

Asymmetric hydrogenolysis of racemic tertiary alcohols, 3-substituted 3-hydroxyisoindolin-1-
ones, was developed using chiral phosphoric acid as catalyst and a Hantzsch ester as the …

An unprecedented highly efficient Lewis acid catalyzed one-pot cascade has been
demonstrated as a general catalytic system for the synthesis of diversely substituted …

Chiral Brønsted acid catalyzed enantioselective syntheses of isoindolinones and phthalides
have been accomplished via tandem Mannich-lactamization and aldol-lactonization …

An organocatalytic direct Mannich–lactamization sequence for the syntheses of
pharmacologically important enantioenriched isoindolinones is reported. The method …