Immune infiltration and clinical significance analyses of the coagulation-related genes in hepatocellular carcinoma

Q He, J Yang, Y Jin - Briefings in bioinformatics, 2022 - academic.oup.com
Hepatocellular carcinoma (HCC) is one of the most common types of cancers and a global
health challenge with a low early diagnosis rate and high mortality. The coagulation …

Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors

Y Liu, D Wang, Z Li, X Li, M Jin, N Jia, X Cui, G Hu… - Scientific reports, 2022 - nature.com
Abstract Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1) is believed to function
as a tumor suppressor, while Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2) as …

The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism

E Benichou, B Seffou, S Topçu, O Renoult… - Nature …, 2024 - nature.com
Cancer cells integrate multiple biosynthetic demands to drive unrestricted proliferation. How
these cellular processes crosstalk to fuel cancer cell growth is still not fully understood. Here …

Effects of cinnamon powder on glucose metabolism in diabetic mice and the molecular mechanisms

Y Liu, F Liu, D Xing, W Wang, Q Yang, S Liao, E Li… - Foods, 2023 - mdpi.com
The liver is the primary organ regulating glucose metabolism. In our recent study, cinnamon
improved liver function in diabetic mice. However, it is not clear whether cinnamon can …

Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Y Jiang, Y Li, C Liu, L Zhang, D Lv, Y Weng… - Nature …, 2021 - nature.com
Isoniazid (INH) is a first-line anti-tuberculosis drug used for nearly 70 years. However, the
mechanism underlying the side effects of INH has remained elusive. Here, we report that …

Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma

JX Wang, XJ Jia, Y Liu, JH Dong, XM Ren, O Xu… - Cancer Cell …, 2020 - Springer
Background Increasing evidence has suggested that microRNAs (miRNAs) act as key post-
transcriptional regulators in tumor progression. Previous studies have confirmed that miR-17 …

Dandelion polysaccharides exert anticancer effect on Hepatocellular carcinoma by inhibiting PI3K/AKT/mTOR pathway and enhancing immune response

F Ren, J Li, X Yuan, Y Wang, K Wu, L Kang… - Journal of Functional …, 2019 - Elsevier
Dandelion polysaccharides (DP) have been reported to possess anticancer activity. In this
study, we showed that DP significantly inhibited Hepatocellular carcinoma (HCC) cell …

Circ_0000215 exerts oncogenic function in nasopharyngeal carcinoma by targeting miR-512-5p

X Chen, W Xu, Z Ma, J Zhu, J Hu, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Background: Increasing circular RNAs (circRNAs) are reported to participate in cancer
progression. Nonetheless, the role of circRNAs in nasopharyngeal carcinoma (NPC) has not …

Bioinformatics Identification of Regulatory Genes and Mechanism Related to Hypoxia-Induced PD-L1 Inhibitor Resistance in Hepatocellular Carcinoma

M Huang, S Yang, WCS Tai, L Zhang, Y Zhou… - International Journal of …, 2023 - mdpi.com
The combination of a PD-L1 inhibitor and an anti-angiogenic agent has become the new
reference standard in the first-line treatment of non-excisable hepatocellular carcinoma …

Exploration of potential targets and mechanisms of fisetin in the treatment of non‐small‐cell lung carcinoma via network pharmacology and in vitro validation

J Ling, Y Wang, L Ma, A Chang… - Evidence‐Based …, 2022 - Wiley Online Library
Purpose. The morbidity and fatality rates of non‐small‐cell lung cancer (NSCLC) were high,
although a combination of multiple treatments was used. Fisetin, a small flavonoid …