The population is aging at a rate never seen before in human history. As the number of
elderly adults grows, it is imperative we expand our understanding of the underpinnings of …

Skeletal muscle has a high capacity to repair and remodel in response to damage, largely
through the action of resident muscle stem cells, termed satellite cells. Satellite cells are …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

Alveolar macrophages orchestrate the response to viral infections. Age-related changes in
these cells may underlie the differential severity of pneumonia in older patients. We …

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
been considered a public health emergency, extensively investigated by researchers …

Attraction, retention, and differentiation of leukocytes to and within the kidney are governed
by chemokines. The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 are …

Skeletal muscle possesses a high plasticity and a remarkable regenerative capacity that
relies mainly on muscle stem cells (MuSCs). Molecular and cellular components of the …

The aging population is at a higher risk for age-related diseases and infections. This
observation could be due to immunosenescence: the decline in immune efficacy of both the …

Age-related decline in skeletal muscle regenerative capacity is multifactorial, yet the
contribution of immune dysfunction to regenerative failure is unknown. Macrophages are …

The incidence and severity of metabolic diseases can be reduced by introducing healthy
lifestyle habits including moderate exercise. A common observation in age-related metabolic …