Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

Intake of salt is a biological imperative, inextricably woven into physiological systems,
human societies and global culture. However, excessive salt intake is associated with high …

Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting
delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Significance: Chronic kidney disease (CKD) can be regarded as a burden of lifestyle
disease that shares common underpinning features and risk factors with the aging process; …

Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have
a high specific metabolic rate, play an essential role in the long-term regulation of arterial …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

The development of essential hypertension involves several factors. Vascular dysfunction,
characterized by endothelial dysfunction, low-grade inflammation and structural remodeling …

The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Alzheimer disease (AD) is marked by profound neurodegeneration, neuroinflammation, and
cognitive decline. Pathologically, AD is characterized by the accumulation of extracellular …