Work with human specific viruses will greatly benefit from the use of an in vivo system that
provides human target cells and tissues in a physiological setting. In this regard humanized …

The study of human-specific infectious agents has been hindered by the lack of optimal
small animal models. More recently development of novel strains of immunodeficient mice …

Experimental studies of Plasmodium parasites that infect humans are restricted by their host
specificity. Humanized mice offer a means to overcome this and further provide the …

Plasmodium falciparum, which causes the most lethal form of human malaria, replicates in
the host liver during the initial stage of infection. However, in vivo malaria liver-stage (LS) …

Mycobacterium tuberculosis (M. tb) is the second leading infectious cause of death
worldwide and the primary cause of death in people living with HIV/AIDS. There are several …

The lack of knowledge about the mechanism of erythrocyte biogenesis through self-
replication makes the in vitro generation of large quantities of cells difficult. We show that …

Malaria is a disease caused by infection with Plasmodium parasites that are transmitted by
mosquito bite. Five different species of Plasmodium infect humans with severe disease, but …

Rheumatoid arthritis (RA) is an inflammatory, autoimmune and connective-tissue
arthropathy. The methotrexate (MTX) and aceclofenac (ACL) combination drug regimen is …

The mechanisms underlying Plasmodium falciparum resistance in persons with sickle trait
have been under active investigation for more than a half century. This Perspective reviews …

The development of new combinations of antimalarial drugs is urgently needed to prevent
the spread of parasites resistant to drugs in clinical use and contribute to the control and …