Advances in the field of pediatric anesthesiology have enabled the performance of complex
and life-saving procedures with minimal patient discomfort. However, preclinical studies …

Advances have been made in the field of developmental anesthetic neurotoxicity over the
past few years, including the recognition that anesthetic exposure is associated with deficits …

Postoperative cognitive dysfunction (POCD) is a common surgical complication that causes
additional pain in patients and affects their quality of life. To address this problem, emerging …

Background Melatonin is known to have protective effects in aging, neurodegenerative
disorders and mitochondria-related diseases, while there is a poor understanding of the …

General anesthetics are potent neurotoxins when given during early development, causing
apoptotic deletion of substantial number of neurons and persistent neurocognitive and …

Background Repeated neonatal sevoflurane exposures led to neurocognitive disorders in
young mice. We aimed to assess the role of microglia and complement C1q in sevoflurane …

EditordIncreasing evidence suggests that inflammation and exposure to general anaesthetic
drugs trigger long-lasting changes in brain function that may contribute to perioperative …

Chronic kidney disease (CKD) is a growing global public health issue. Ginsenoside Rg1
(Rg1) has favorable nephroprotective effects, but its role and mechanism in CKD need …

Behavioural disorders after prenatal exposure to anaesthesia for maternal surgery: is it the
anaesthesia or the surgery? Comment on Br J Anaesth 2024; 132: 899–910 - PMC Skip to main …

Anesthetic-induced developmental neurotoxicity (AIDN) can arise due to various factors,
among which aberrant nerve cell death is a prominent risk factor. Animal studies have …