Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

Acquired mutations are pervasive across normal tissues. However, understanding of the
processes that drive transformation of certain clones to cancer is limited. Here we study this …

Abstract The European Collaborative on Personalized Early Detection and Prevention of
Breast Cancer (ENVISION) brings together several international research consortia working …

Accurate genetic prediction of complex traits can facilitate disease screening, improve early
intervention, and aid in the development of personalized medicine. Genetic prediction of …

Background The multifactorial Breast and Ovarian Analysis of Disease Incidence and
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …

Accurate prediction of disease risk based on the genetic make-up of an individual is
essential for effective prevention and personalized treatment. Nevertheless, to date …

Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from
mainly European ancestry (EA) cohorts, their validity in African ancestry (AA) and Hispanic …

Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases,
optimizing treatment, and predicting survival outcomes. Here, we construct and validate a …

Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …