In vitro plant tissue culture: means for production of biological active compounds

CA Espinosa-Leal, CA Puente-Garza, S García-Lara - Planta, 2018 - Springer
Main conclusion Plant tissue culture as an important tool for the continuous production of
active compounds including secondary metabolites and engineered molecules. Novel …

Plant-based biopharmaceutical engineering

L Eidenberger, B Kogelmann… - Nature Reviews …, 2023 - nature.com
Plants can be engineered to recombinantly produce high-quality proteins such as
therapeutic proteins and vaccines, also known as molecular farming. Molecular farming can …

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

D Ghaderi, M Zhang, N Hurtado-Ziola… - Biotechnology and …, 2012 - Taylor & Francis
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …

Plant molecular pharming for the treatment of chronic and infectious diseases

E Stoger, R Fischer, M Moloney… - Annual review of plant …, 2014 - annualreviews.org
Plant molecular pharming has emerged as a niche technology for the manufacture of
pharmaceutical products indicated for chronic and infectious diseases, particularly for …

[HTML][HTML] Plant glycoengineering for designing next-generation vaccines and therapeutic proteins

R Strasser - Biotechnology Advances, 2023 - Elsevier
Protein glycosylation has a huge impact on biological processes in all domains of life. The
type of glycan present on a recombinant glycoprotein depends on protein intrinsic features …

Advanced plant-based glycan engineering

L Montero-Morales, H Steinkellner - Frontiers in Bioengineering and …, 2018 - frontiersin.org
With respect to biomanufacturing, glycosylation is one of the most addressed post-
translational modifications, since it is well-known that the attachment of sugar residues …

Manufacturing economics of plant‐made biologics: case studies in therapeutic and industrial enzymes

D Tusé, T Tu, KA McDonald - BioMed research international, 2014 - Wiley Online Library
Production of recombinant biologics in plants has received considerable attention as an
alternative platform to traditional microbial and animal cell culture. Industrially relevant …

Glycoengineering of antibodies for modulating functions

LX Wang, X Tong, C Li, JP Giddens… - Annual review of …, 2019 - annualreviews.org
Antibodies are immunoglobulins that play essential roles in immune systems. All antibodies
are glycoproteins that carry at least one or more conserved N-linked oligosaccharides (N …

N-glycosylation of the SARS-CoV-2 receptor binding domain is important for functional expression in plants

YJ Shin, J König-Beihammer, U Vavra… - Frontiers in Plant …, 2021 - frontiersin.org
Nicotiana benthamiana is used worldwide as production host for recombinant proteins.
Many recombinant proteins such as monoclonal antibodies, growth factors or viral antigens …

Plant-derived virus-like particles as vaccines

Q Chen, H Lai - Human vaccines & immunotherapeutics, 2013 - Taylor & Francis
Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …