The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …

New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric
features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised …

This work describes the design and synthesis of new hybrids of thienopyrimidine and
sulfonamides. The binding affinity of the prepared compounds to FGFR-1 enzyme and …

Abstract A series of pyrrolo [2, 3-d] pyrimidine linked to diarylureas were previously
discovered by our group as sorafenib fused congeners, which were endowed with more …

Abstract A series of novel 6, 7-dihydro-5H-cyclopenta [d] pyrimidine derivatives was
successfully designed, synthesized and evaluated as a new chemical scaffold with vascular …

In the present study, two novel series of compounds incorporating naphthyl and pyridyl
linker were synthesized and biological assays revealed 5-((6-(2-(5-(2-chlorophenyl)-3-(4 …

In our attempt to discover effective anticancer agents, three series of novel quinazoline-
based compounds have been designed, synthesized and tested as VEGFR-2 inhibitors. Five …

In anticancer drug discovery, multi-targeting compounds have been beneficial due to their
advantages over single-targeting compounds. For instance, VEGFR-2 has a crucial role in …

Heterocyclic compounds are recognized to possess a high grade of structural diversity and a
broad spectrum of therapeutic properties. About two-thirds of the New Chemical Entities …