Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

The vertebrate intestine forms by asymmetric gut rotation and elongation, and errors cause
lethal obstructions in human infants. Rotation begins with tissue deformation of the dorsal …

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate
embryonic body plan. Nodal signaling is essential for the specification of mesendodermal …

Vertebrates exhibit striking left–right (L–R) asymmetries in the structure and position of the
internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow …

Understanding how left–right (LR) asymmetry is generated in vertebrate embryos is an
important problem in developmental biology. In humans, a failure to align the left and right …

The dorsal mesentery (DM) is the major conduit for blood and lymphatic vessels in the gut.
The mechanisms underlying their morphogenesis are challenging to study and remain …

Wnt signaling plays an essential role in developmental and regenerative myelination of the
CNS; however, contributions of proximal regulators of the Wnt receptor complex to these …

The phenomenon of planar cell polarity is critically required for a myriad of morphogenetic
processes in metazoan and is accurately controlled by several conserved modules. Six …

For many years, biologists have focused on the role of Pitx2, expressed on the left side of
developing embryos, in governing organ laterality. Here, we identify a different pathway …