Cognition in multiple sclerosis: State of the field and priorities for the future

JF Sumowski, R Benedict, C Enzinger, M Filippi… - Neurology, 2018 - AAN Enterprises
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis
(MS), especially deficits in episodic memory and processing speed. The field aims to (1) …

Remyelination therapies: a new direction and challenge in multiple sclerosis

JR Plemel, WQ Liu, VW Yong - Nature reviews Drug discovery, 2017 - nature.com
Multiple sclerosis is characterized by inflammatory activity that results in destruction of the
myelin sheaths that enwrap axons. The currently available medications for multiple sclerosis …

Association between pathological and MRI findings in multiple sclerosis

M Filippi, W Brück, D Chard, F Fazekas… - The Lancet …, 2019 - thelancet.com
Pathological evaluation is the gold standard for identifying processes related to multiple
sclerosis that explain disease manifestations, and for guiding the development of new …

Cognition in multiple sclerosis

DW Langdon - Current opinion in neurology, 2011 - journals.lww.com
Cognition in multiple sclerosis : Current Opinion in Neurology Cognition in multiple sclerosis :
Current Opinion in Neurology Log in or Register Subscribe to journalSubscribe Get new …

Risk factors for and management of cognitive dysfunction in multiple sclerosis

RHB Benedict, R Zivadinov - Nature Reviews Neurology, 2011 - nature.com
Cognitive impairment is common in multiple sclerosis (MS), especially when assessed by
neuropsychological tests that emphasize mental processing speed, episodic memory, and …

White matter diseases with radiologic-pathologic correlation

N Sarbu, RY Shih, RV Jones, I Horkayne-Szakaly… - Radiographics, 2016 - pubs.rsna.org
White matter diseases include a wide spectrum of disorders that have in common
impairment of normal myelination, either by secondary destruction of previously myelinated …

Measurement and clinical effect of grey matter pathology in multiple sclerosis

JJG Geurts, M Calabrese, E Fisher… - The Lancet …, 2012 - thelancet.com
During the past 10 years, the intense involvement of the grey matter of the CNS in the
pathology of multiple sclerosis has become evident. On gross inspection, demyelination in …

Information processing speed in multiple sclerosis: Past, present, and future

SL Costa, HM Genova, J DeLuca… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Background: Information processing speed (IPS) is a prevalent cognitive impairment in
multiple sclerosis (MS). Objectives: This review aims to summarize the methods applied to …

Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination

CL Call, DE Bergles - Nature communications, 2021 - nature.com
Axons in the cerebral cortex show a broad range of myelin coverage. Oligodendrocytes
establish this pattern by selecting a cohort of axons for myelination; however, the distribution …

Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis

DY Kim, J Hao, R Liu, G Turner, FD Shi, JM Rho - PloS one, 2012 - journals.plos.org
A prominent clinical symptom in multiple sclerosis (MS), a progressive disorder of the central
nervous system (CNS) due to heightened neuro-inflammation, is learning and memory …