MicroRNAs (miRNAs) are small non-coding RNAs with a length of about 19–25 nt, which
can regulate various target genes and are thus involved in the regulation of a variety of …

The p63 gene is a member of the p53/p63/p73 family of transcription factors and plays a
critical role in development and homeostasis of squamous epithelium. p63 is transcribed as …

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …

Glioblastoma multiforme (GBM) is the most malignant brain tumor with limited therapeutic
options. Temozolomide (TMZ) is a novel cytotoxic agent used as first-line chemotherapy for …

The p53 family member TAp73 is a transcription factor that plays a key role in many
biological processes, including neuronal development. In particular, we have shown that …

In mammals, the p53 family comprises two additional members, p63 and p73 (hereafter
referred to as TP 53, TP 63, and TP 73, respectively). The usage of two alternative promoters …

Although microRNAs (miRNA) have been broadly studied in cancer, comparatively less is
understood about their role in progression. Here we report that miR-153 has a dual role …

Objective We undertook this study to examine microRNA (miRNA) expression across
rheumatoid arthritis (RA) phenotypes, along with the effects and mechanisms of action of …

Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly
reduces a cancer patient's likelihood of long-term survival. The ZEB1 transcriptional …

A number of anti-cancer strategies aim to target the mitochondrial apoptotic machinery to
induce tumour cell death. Mitochondria play a key role as death amplifiers by releasing …