The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular …

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …

The organization of a cell emerges from the interactions in protein networks. The
interactome is critically dependent on the strengths of interactions and the cellular …

Summary The CyclinB1-Cdk1 kinase is the catalytic activity at the heart of mitosis-promoting
factor (MPF), yet fundamental questions concerning its role in mitosis remained unresolved …

The eukaryotic cell division cycle is characterized by a sequence of orderly and highly
regulated events resulting in the duplication and separation of all cellular material into two …

Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis
and cytokinesis. In agreement with a broad range of proposed functions during cell division …

The appropriate timing of events that lead to chromosome segregation during mitosis and
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …

In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each
daughter cell inherits an identical set of chromosomes. The SAC coordinates the correct …

One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …