Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …

A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …

How transcription affects genome 3D organization is not well understood. We found that
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …

Macrophages are crucial members of the innate immune response and important regulators.
The differentiation and activation of macrophages require the timely regulation of gene …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a
growing public health concern. Systems-level analysis of how flaviviruses hijack cellular …

To date, there is rapidly increasing evidence for host–microbe interaction at virtually all
levels of complexity, ranging from direct cell‐to‐cell communication to extensive systemic …

Finding the components of cellular circuits and determining their functions systematically
remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled …