Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

[HTML][HTML] Plant-derived anticancer agents: A green anticancer approach

J Iqbal, BA Abbasi, T Mahmood, S Kanwal, B Ali… - Asian Pacific Journal of …, 2017 - Elsevier
Cancer is a frightful disease and represents one of the biggest health-care issues for the
human race and demands a proactive strategy for cure. Plants are reservoirs for novel …

Status and challenges of plant-anticancer compounds in cancer treatment

P Garcia-Oliveira, P Otero, AG Pereira, F Chamorro… - Pharmaceuticals, 2021 - mdpi.com
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …

[HTML][HTML] An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin

S Bastani, V Vahedian, M Rashidi, A Mir… - Biomedicine & …, 2022 - Elsevier
Crocin, an active ingredient derived from saffron, is one of the herbal components that has
recently been considered by researchers. Crocin has been shown to have many anti …

Therapeutic effects of crocin alone or in combination with sorafenib against hepatocellular carcinoma: in vivo & in vitro insights

S Abdu, N Juaid, A Amin, M Moulay, N Miled - Antioxidants, 2022 - mdpi.com
This study investigated the therapeutic effects of the phytochemical crocin alone or in
combination with sorafenib both in rats chemically induced with hepatocellular carcinoma …

[HTML][HTML] A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids

SI Bukhari, M Manzoor, MK Dhar - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Crocus sativus is an herbaceous plant that belongs to family Iridaceae. It is commonly
known as saffron and has been used for medicinal purposes since many centuries in India …

[HTML][HTML] Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review

M Zeinali, MR Zirak, SA Rezaee, G Karimi… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history
in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …

Molecular mechanisms behind safranal's toxicity to HepG2 cells from dual omics

DR Nelson, AA Hrout, AS Alzahmi, A Chaiboonchoe… - Antioxidants, 2022 - mdpi.com
The spice saffron (Crocus sativus) has anticancer activity in several human tissues, but the
molecular mechanisms underlying its potential therapeutic effects are poorly understood …

Recent Advances on the Anticancer Properties of Saffron (Crocus sativus L.) and Its Major Constituents

A Lambrianidou, F Koutsougianni, I Papapostolou… - Molecules, 2020 - mdpi.com
Cancer is the second leading cause of death globally with an estimated 9.6 million deaths in
2018 and a sustained rise in its incidence in both developing and developed countries …

The role of Safranal and saffron stigma extracts in oxidative stress, diseases and photoaging: A systematic review

S Nanda, K Madan - Heliyon, 2021 - cell.com
Reactive oxygen species (ROS) are produced as a result of various environmental factors
and cellular metabolism reactions creating oxidative stress. The reversible oxidative …