Type 2 diabetes mellitus in sub-Saharan Africa: challenges and opportunities
Type 2 diabetes mellitus (T2DM), which was once thought to be rare in sub-Saharan Africa
(SSA), is now well established in this region. The SSA region is undergoing a rapid but …
(SSA), is now well established in this region. The SSA region is undergoing a rapid but …
Prevalence of type 2 diabetes in South Africa: a systematic review and meta-analysis
Synthesis of existing prevalence data using rigorous systematic review methods is
considered an effective strategy to generate representative and robust prevalence figures to …
considered an effective strategy to generate representative and robust prevalence figures to …
Diagnostic accuracy of tests for type 2 diabetes and prediabetes: A systematic review and meta-analysis
Aim This systematic review aimed to ascertain the diagnostic accuracy (sensitivity and
specificity) of screening tests for early detection of type 2 diabetes and prediabetes in …
specificity) of screening tests for early detection of type 2 diabetes and prediabetes in …
ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response
AA Adeyemo, NA Zaghloul, G Chen… - Nature …, 2019 - nature.com
Genome analysis of diverse human populations has contributed to the identification of novel
genomic loci for diseases of major clinical and public health impact. Here, we report a …
genomic loci for diseases of major clinical and public health impact. Here, we report a …
Genome-wide association study of type 2 diabetes in Africa
Aims/hypothesis Genome-wide association studies (GWAS) for type 2 diabetes have
uncovered> 400 risk loci, primarily in populations of European and Asian ancestry. Here, we …
uncovered> 400 risk loci, primarily in populations of European and Asian ancestry. Here, we …
The prevalence of type 2 diabetes in South Africa: a systematic review protocol
C Pheiffer, V Pillay-van Wyk, JD Joubert, N Levitt… - BMJ open, 2018 - bmjopen.bmj.com
Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South
Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local …
Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local …
Trilateral overlap of tuberculosis, diabetes and HIV-1 in a high-burden African setting: implications for TB control
T Oni, N Berkowitz, M Kubjane… - European …, 2017 - Eur Respiratory Soc
The diabetes mellitus burden is growing in countries where tuberculosis (TB) and HIV-1
remain major challenges, threatening TB control efforts. This study determined the …
remain major challenges, threatening TB control efforts. This study determined the …
Alternative indices of glucose homeostasis as biochemical diagnostic tests for abnormal glucose tolerance in an African setting
Aims Accurate diabetes diagnosis is important in Africa, where rates are increasing, and the
disease largely undiagnosed. The cumbersome oral glucose tolerance test (OGTT) remains …
disease largely undiagnosed. The cumbersome oral glucose tolerance test (OGTT) remains …
The diagnostic accuracy of HbA1c, compared to the oral glucose tolerance test, for screening for type 2 diabetes mellitus in Africa—A systematic review and meta …
Objective To assess the diagnostic accuracy of glycated haemoglobin A1c (HbA1c),
compared to fasting plasma glucose (FPG) and the oral glucose tolerance test (OGTT), in …
compared to fasting plasma glucose (FPG) and the oral glucose tolerance test (OGTT), in …
Access to hemoglobin A1c in rural Africa: a difficult reality with severe consequences
PH Park, SD Pastakia - Journal of diabetes research, 2018 - Wiley Online Library
Sub‐Saharan Africa (SSA) continues to have the highest diabetes‐related mortality rate in
the world. While there exists a multitude of health system barriers driving poor diabetes …
the world. While there exists a multitude of health system barriers driving poor diabetes …