Type 2 diabetes mellitus in sub-Saharan Africa: challenges and opportunities

AA Motala, JC Mbanya, K Ramaiya, FJ Pirie… - Nature Reviews …, 2022 - nature.com
Type 2 diabetes mellitus (T2DM), which was once thought to be rare in sub-Saharan Africa
(SSA), is now well established in this region. The SSA region is undergoing a rapid but …

Prevalence of type 2 diabetes in South Africa: a systematic review and meta-analysis

C Pheiffer, V Pillay-van Wyk, E Turawa, N Levitt… - International journal of …, 2021 - mdpi.com
Synthesis of existing prevalence data using rigorous systematic review methods is
considered an effective strategy to generate representative and robust prevalence figures to …

Diagnostic accuracy of tests for type 2 diabetes and prediabetes: A systematic review and meta-analysis

G Kaur, PVM Lakshmi, A Rastogi, A Bhansali, S Jain… - PloS one, 2020 - journals.plos.org
Aim This systematic review aimed to ascertain the diagnostic accuracy (sensitivity and
specificity) of screening tests for early detection of type 2 diabetes and prediabetes in …

ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response

AA Adeyemo, NA Zaghloul, G Chen… - Nature …, 2019 - nature.com
Genome analysis of diverse human populations has contributed to the identification of novel
genomic loci for diseases of major clinical and public health impact. Here, we report a …

Genome-wide association study of type 2 diabetes in Africa

J Chen, M Sun, A Adeyemo, F Pirie, T Carstensen… - Diabetologia, 2019 - Springer
Aims/hypothesis Genome-wide association studies (GWAS) for type 2 diabetes have
uncovered> 400 risk loci, primarily in populations of European and Asian ancestry. Here, we …

The prevalence of type 2 diabetes in South Africa: a systematic review protocol

C Pheiffer, V Pillay-van Wyk, JD Joubert, N Levitt… - BMJ open, 2018 - bmjopen.bmj.com
Introduction Type 2 diabetes mellitus is a major source of morbidity and mortality in South
Africa, spurred by increased urbanisation and unhealthy lifestyle factors. Local …

Trilateral overlap of tuberculosis, diabetes and HIV-1 in a high-burden African setting: implications for TB control

T Oni, N Berkowitz, M Kubjane… - European …, 2017 - Eur Respiratory Soc
The diabetes mellitus burden is growing in countries where tuberculosis (TB) and HIV-1
remain major challenges, threatening TB control efforts. This study determined the …

Alternative indices of glucose homeostasis as biochemical diagnostic tests for abnormal glucose tolerance in an African setting

AP Kengne, RT Erasmus, NS Levitt, TE Matsha - Primary care diabetes, 2017 - Elsevier
Aims Accurate diabetes diagnosis is important in Africa, where rates are increasing, and the
disease largely undiagnosed. The cumbersome oral glucose tolerance test (OGTT) remains …

The diagnostic accuracy of HbA1c, compared to the oral glucose tolerance test, for screening for type 2 diabetes mellitus in Africa—A systematic review and meta …

T Chivese, J Hirst, JT Matizanadzo… - Diabetic …, 2022 - Wiley Online Library
Objective To assess the diagnostic accuracy of glycated haemoglobin A1c (HbA1c),
compared to fasting plasma glucose (FPG) and the oral glucose tolerance test (OGTT), in …

Access to hemoglobin A1c in rural Africa: a difficult reality with severe consequences

PH Park, SD Pastakia - Journal of diabetes research, 2018 - Wiley Online Library
Sub‐Saharan Africa (SSA) continues to have the highest diabetes‐related mortality rate in
the world. While there exists a multitude of health system barriers driving poor diabetes …