The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …

(1) Background: Inflammation is a major pathomechanism in the development and
progression of age-related macular degeneration (AMD). The retinal pigment epithelium …

Rationale: There is incomplete knowledge of the impact of bone marrow cells on the gut
microbiome and gut barrier function. Objective: We postulated that diabetes mellitus and …

Age-related macular degeneration (AMD) is a progressive neurodegenerative disease
affecting the central area (macula lutea) of the retina. Research on the pathogenic …

Diabetic retinopathy (DR), a secondary complication of diabetes, is a leading cause of
irreversible blindness accounting for 5% of world blindness cases in working age. Oxidative …

Background Clustering of microglia around the vasculature has been reported in the retina
and the brain after systemic administration of lipopolysaccharides (LPS) in mice. LPS acts …

Importance Visual acuity (VA) outcomes differ considerably among patients with
neovascular age-related macular degeneration (nAMD) treated with anti–vascular …

Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible
visual impairment in the elderly. The current management of nAMD is limited and involves …

Angiogenesis, a prominent feature of pathology, is known to be guided by factors secreted
by living cells around a lesion. Although many cells are disrupted in a response to injury, the …

The uveal tract consists of the iris, the ciliary body and the choroid; these three distinct
tissues form a continuous layer within the eye. Uveitis refers to inflammation of any region of …