RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

The transcription factor PU. 1 is often impaired in patients with acute myeloid leukemia
(AML). Here, we used AML cells that already had low PU. 1 levels and further inhibited PU. 1 …

Mutations in acute myeloid leukemia (AML)-associated oncogenes often arise in
hematopoietic stem cells (HSCs) and promote acquisition of leukemia stem cell (LSC) …

RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or
germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute myeloid …

The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional
blood cells requires the finely tuned regulation of gene expression at each stage of …

The Ets transcription factor PU. 1 is essential for inducing the differentiation of monocytes,
macrophages, and B cells in fetal liver and adult bone marrow. PU. 1 controls hematopoietic …

B cell acute lymphoblastic leukemia (B-ALL) is a multistep disease characterized by the
hierarchical acquisition of genetic alterations. However, the question of how a primary …

Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …

The mechanism underlying cell type-specific gene induction conferred by ubiquitous
transcription factors as well as disruptions caused by their chimeric derivatives in leukemia …