Role of RUNX1 in hematological malignancies
R Sood, Y Kamikubo, P Liu - … Journal of the American Society of …, 2017 - ashpublications.org
RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
[HTML][HTML] Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer
EH Ervin, R French, CH Chang, S Pauklin - Seminars in cancer biology, 2022 - Elsevier
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …
Pharmacological inhibition of the transcription factor PU. 1 in leukemia
The transcription factor PU. 1 is often impaired in patients with acute myeloid leukemia
(AML). Here, we used AML cells that already had low PU. 1 levels and further inhibited PU. 1 …
(AML). Here, we used AML cells that already had low PU. 1 levels and further inhibited PU. 1 …
Hematopoietic differentiation is required for initiation of acute myeloid leukemia
Mutations in acute myeloid leukemia (AML)-associated oncogenes often arise in
hematopoietic stem cells (HSCs) and promote acquisition of leukemia stem cell (LSC) …
hematopoietic stem cells (HSCs) and promote acquisition of leukemia stem cell (LSC) …
RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1
RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or
germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute myeloid …
germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute myeloid …
The RUNX1–PU. 1 axis in the control of hematopoiesis
MR Imperato, P Cauchy, N Obier, C Bonifer - International journal of …, 2015 - Springer
The differentiation from multipotent hematopoietic stem cells (HSC) to mature and functional
blood cells requires the finely tuned regulation of gene expression at each stage of …
blood cells requires the finely tuned regulation of gene expression at each stage of …
PU. 1-c-Jun interaction is crucial for PU. 1 function in myeloid development
X Zhao, B Bartholdy, Y Yamamoto, EK Evans… - Communications …, 2022 - nature.com
The Ets transcription factor PU. 1 is essential for inducing the differentiation of monocytes,
macrophages, and B cells in fetal liver and adult bone marrow. PU. 1 controls hematopoietic …
macrophages, and B cells in fetal liver and adult bone marrow. PU. 1 controls hematopoietic …
[HTML][HTML] Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL
V Fregona, M Bayet, M Bouttier… - The Journal of …, 2024 - ncbi.nlm.nih.gov
B cell acute lymphoblastic leukemia (B-ALL) is a multistep disease characterized by the
hierarchical acquisition of genetic alterations. However, the question of how a primary …
hierarchical acquisition of genetic alterations. However, the question of how a primary …
Core-binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis
Adenosine-to-inosine RNA editing, which is catalyzed by adenosine deaminases acting on
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …
RNA (ADAR) family of enzymes, ADAR1 and ADAR2, has been shown to contribute to …
Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML
BQ Trinh, S Ummarino, Y Zhang… - Blood, The Journal …, 2021 - ashpublications.org
The mechanism underlying cell type-specific gene induction conferred by ubiquitous
transcription factors as well as disruptions caused by their chimeric derivatives in leukemia …
transcription factors as well as disruptions caused by their chimeric derivatives in leukemia …