Complement component C3–The “Swiss Army Knife” of innate immunity and host defense
As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …
Tipping the balance: intricate roles of the complement system in disease and therapy
The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
J Yu, X Yuan, H Chen, S Chaturvedi… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
Protection of host cells by complement regulators
CQ Schmidt, JD Lambris, D Ricklin - Immunological reviews, 2016 - Wiley Online Library
The complement cascade is an ancient immune‐surveillance system that not only provides
protection from pathogen invasion but has also evolved to participate in physiological …
protection from pathogen invasion but has also evolved to participate in physiological …
Complement factor H in host defense and immune evasion
Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
pathogen-and damage-associated molecular patterns, and initiates the immune response in …
Hijacking factor H for complement immune evasion
The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …
three pathways (alternative, classical, and lectin) that initiate either spontaneously …
Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches*[S]
Oral cavity squamous cell carcinoma (OSCC) is one of the most common cancers
worldwide. In Taiwan, OSCC is the fifth leading cause of cancer-related mortality and leads …
worldwide. In Taiwan, OSCC is the fifth leading cause of cancer-related mortality and leads …
Hijacking complement regulatory proteins for bacterial immune evasion
ES Hovingh, B Van den Broek, I Jongerius - Frontiers in Microbiology, 2016 - frontiersin.org
The human complement system plays an important role in the defense against invading
pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly …
pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly …
Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity
GO Andre, TR Converso, WR Politano… - Frontiers in …, 2017 - frontiersin.org
The complement system plays a central role in immune defense against Streptococcus
pneumoniae. In order to evade complement attack, pneumococci have evolved a number of …
pneumoniae. In order to evade complement attack, pneumococci have evolved a number of …
Cloaking silica nanoparticles with functional protein coatings for reduced complement activation and cellular uptake
JH Park, JA Jackman, AR Ferhan, JN Belling… - ACS …, 2020 - ACS Publications
Silica-coated nanoparticles are widely used in biomedical applications such as theranostics,
imaging, and drug delivery. While silica-coated nanoparticles are biocompatible …
imaging, and drug delivery. While silica-coated nanoparticles are biocompatible …