Heart function and hemodynamic analysis for zebrafish embryos

HC Yalcin, A Amindari, JT Butcher… - Developmental …, 2017 - Wiley Online Library
The Zebrafish has emerged to become a powerful vertebrate animal model for
cardiovascular research in recent years. Its advantages include easy genetic manipulation …

The zebrafish as a tool to identify novel therapies for human cardiovascular disease

A Asnani, RT Peterson - Disease models & mechanisms, 2014 - journals.biologists.com
Over the past decade, the zebrafish has become an increasingly popular animal model for
the study of human cardiovascular disease. Because zebrafish embryos are transparent and …

6: 2 Chlorinated polyfluorinated ether sulfonate, a PFOS alternative, induces embryotoxicity and disrupts cardiac development in zebrafish embryos

G Shi, Q Cui, Y Pan, N Sheng, S Sun, Y Guo, J Dai - Aquatic Toxicology, 2017 - Elsevier
As an alternative to perfluorooctanesulfonate (PFOS), 6: 2 chlorinated polyfluorinated ether
sulfonate (commercial name: F-53B) has been used as a mist suppressant in Chinese …

Computational profiling of hiPSC-derived heart organoids reveals chamber defects associated with NKX2-5 deficiency

W Feng, H Schriever, S Jiang, A Bais, H Wu… - Communications …, 2022 - nature.com
Heart organoids have the potential to generate primary heart-like anatomical structures and
hold great promise as in vitro models for cardiac disease. However, their properties have not …

Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos

Y Huang, J Ma, Y Meng, Y Wei, S Xie, P Jiang… - Environmental …, 2020 - Elsevier
Oxadiazon-Butachlor (OB) is a widely used herbicide for controlling most annual weeds in
rice fields. However, its potential toxicity in aquatic organisms has not been evaluated so far …

In vivo dissection of chamber-selective enhancers reveals estrogen-related receptor as a regulator of ventricular cardiomyocyte identity

Y Cao, X Zhang, BN Akerberg, H Yuan, T Sakamoto… - Circulation, 2023 - Am Heart Assoc
Background: Cardiac chamber-selective transcriptional programs underpin the structural
and functional differences between atrial and ventricular cardiomyocytes (aCMs and vCMs) …

Exposure to acrylamide induces cardiac developmental toxicity in zebrafish during cardiogenesis

M Huang, J Jiao, J Wang, Z Xia, Y Zhang - Environmental pollution, 2018 - Elsevier
Acrylamide (AA), an environmental pollutant, has been linked to neurotoxicity, genotoxicity
and carcinogenicity. AA is widely used to synthesize polymers for industrial applications, is …

[PDF][PDF] Canonical Wnt5b signaling directs outlying Nkx2. 5+ mesoderm into pacemaker cardiomyocytes

J Ren, P Han, X Ma, EN Farah, J Bloomekatz… - Developmental cell, 2019 - cell.com
Pacemaker cardiomyocytes that create the sinoatrial node are essential for the initiation and
maintenance of proper heart rhythm. However, illuminating developmental cues that direct …

Risk assessment of cardiotoxicity to zebrafish (Danio rerio) by environmental exposure to triclosan and its derivatives

D Wang, Y Zhang, J Li, RA Dahlgren, X Wang… - Environmental …, 2020 - Elsevier
Triclosan (TCS) and its two derivatives (2, 4-dichlorophenol and 2, 4, 6-trichlorophenol) are
priority pollutants that coexist in aquatic environments. Joint exposure of TCS, 2, 4 …

[HTML][HTML] An early requirement for nkx2. 5 ensures the first and second heart field ventricular identity and cardiac function into adulthood

V George, S Colombo, KL Targoff - Developmental biology, 2015 - Elsevier
Temporally controlled mechanisms that define the unique features of ventricular and atrial
cardiomyocyte identities are essential for the construction of a coordinated, morphologically …