[HTML][HTML] The role of CXCR3 and its chemokine ligands in skin disease and cancer
Chemokines and their receptors play an important role in the recruitment, activation and
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …
[HTML][HTML] Modulation of antigen presenting cell functions during chronic HPV infection
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some
individuals they evade host immune responses and persist. Persistent HR-HPV infection of …
individuals they evade host immune responses and persist. Persistent HR-HPV infection of …
[HTML][HTML] Human papillomavirus and the stroma: bidirectional crosstalk during the virus life cycle and carcinogenesis
ME Spurgeon, PF Lambert - Viruses, 2017 - mdpi.com
Human papillomaviruses (HPVs) are double-stranded DNA (dsDNA) tumor viruses that are
causally associated with human cancers of the anogenital tract, skin, and oral cavity. Despite …
causally associated with human cancers of the anogenital tract, skin, and oral cavity. Despite …
IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia
C Gosmann, SR Mattarollo, JA Bridge… - The Journal of …, 2014 - journals.aai.org
Persistent infection with high-risk human papillomaviruses (HPV) causes epithelial
hyperplasia that can progress to cancer and is thought to depend on immunosuppressive …
hyperplasia that can progress to cancer and is thought to depend on immunosuppressive …
[HTML][HTML] HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2-and CCL5-mediated recruitment of mast cells
Human Papillomavirus (HPV) 16 E7 protein promotes the transformation of HPV infected
epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is …
epithelium to malignancy. Here, we use a murine model in which the E7 protein of HPV16 is …
Recent progress in vaccination against human papillomavirus‐mediated cervical cancer
SJ McKee, AS Bergot… - Reviews in medical …, 2015 - Wiley Online Library
It has been more than 7 years since the commercial introduction of highly successful
vaccines protecting against high‐risk human papillomavirus (HPV) subtypes and the …
vaccines protecting against high‐risk human papillomavirus (HPV) subtypes and the …
The interaction between human papillomaviruses and the stromal microenvironment
B Woodby, M Scott, J Bodily - … in molecular biology and translational science, 2016 - Elsevier
Human papillomaviruses (HPVs) are small, double-stranded DNA viruses that replicate in
stratified squamous epithelia and cause a variety of malignancies. Current efforts in HPV …
stratified squamous epithelia and cause a variety of malignancies. Current efforts in HPV …
[HTML][HTML] HPV16E7-induced hyperplasia promotes CXCL9/10 expression and induces CXCR3+ T-cell migration to skin
Chemokines regulate tissue immunity by recruiting specific subsets of immune cells. Mice
expressing the E7 protein of human papilloma virus 16 as a transgene from a keratin 14 …
expressing the E7 protein of human papilloma virus 16 as a transgene from a keratin 14 …
[HTML][HTML] IL-18, but not IL-12, induces production of IFN-γ in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin
IFN-γ has a central role in the defense against infections and cancer. More recently,
however, IFN-γ has also been reported to have immunosuppressive effects in models of …
however, IFN-γ has also been reported to have immunosuppressive effects in models of …
[HTML][HTML] A mouse model of hyperproliferative human epithelium validated by keratin profiling shows an aberrant cytoskeletal response to injury
A validated animal model would assist with research on the immunological consequences of
the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human …
the chronic expression of stress keratins KRT6, KRT16, and KRT17, as observed in human …