CircRNA in cancer: fundamental mechanism and clinical potential
Abstract Circular RNAs (CircRNAs) are a class of single-stranded noncoding RNAs that are
formed in a circular conformation via non-canonical splicing or back-splicing events …
formed in a circular conformation via non-canonical splicing or back-splicing events …
CircRNAs: role in human diseases and potential use as biomarkers
L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …
[HTML][HTML] Circular RNA-protein interactions: functions, mechanisms, and identification
A Huang, H Zheng, Z Wu, M Chen, Y Huang - Theranostics, 2020 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) are covalently closed, endogenous RNAs with no 5′ end caps or
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …
3′ poly (A) tails. These RNAs are expressed in tissue-specific, cell-specific, and …
circRNA_0025202 regulates tamoxifen sensitivity and tumor progression via regulating the miR-182-5p/FOXO3a axis in breast cancer
Y Sang, B Chen, X Song, Y Li, Y Liang, D Han… - Molecular Therapy, 2019 - cell.com
Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor
(HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually …
(HR)-positive breast cancer. Despite its initial therapeutic efficacy, many patients eventually …
[HTML][HTML] A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer
S Wu, J Lu, H Zhu, F Wu, Y Mo, L Xie, C Song, L Liu… - Cancer Letters, 2024 - Elsevier
Among patients with triple-negative breast cancer (TNBC), distant metastasis is the leading
cause of death. Our previous studies have shown that TNBC progression is greatly …
cause of death. Our previous studies have shown that TNBC progression is greatly …
The novel roles of circRNAs in human cancer
Covalently closed single-stranded circular RNAs (circRNAs) consist of introns or exons and
are widely present in eukaryotic cells. CircRNAs generally have low expression levels and …
are widely present in eukaryotic cells. CircRNAs generally have low expression levels and …
[HTML][HTML] Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR
H Liu, T Lan, H Li, L Xu, X Chen, H Liao, X Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: circular RNAs (circRNAs) have been demonstrated to play a crucial role in cancer
progression. KIAA1429, a key component of the m6A methyltransferase complex, has …
progression. KIAA1429, a key component of the m6A methyltransferase complex, has …
circRNA-miRNA-mRNA in breast cancer
M Zhang, X Bai, X Zeng, J Liu, F Liu, Z Zhang - Clinica Chimica Acta, 2021 - Elsevier
Among cancers, breast cancer has the highest incidence rate among women and poses a
tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and …
tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and …
circFBXW7 inhibits malignant progression by sponging miR-197-3p and encoding a 185-aa protein in triple-negative breast cancer
F Ye, G Gao, Y Zou, S Zheng, L Zhang, X Ou… - … Therapy-Nucleic Acids, 2019 - cell.com
Accumulating evidence indicates that circular RNAs (circRNAs) are vital regulators of
various biological functions involved in the progression of multiple cancers. Circular F-box …
various biological functions involved in the progression of multiple cancers. Circular F-box …
Roles of circRNAs in the tumour microenvironment
Q Zhang, W Wang, Q Zhou, C Chen, W Yuan, J Liu… - Molecular cancer, 2020 - Springer
The tumour microenvironment (TME) constitutes the area surrounding the tumour during its
development and has been demonstrated to play roles in cancer-related diseases through …
development and has been demonstrated to play roles in cancer-related diseases through …