RPE cells are the most actively phagocytic cells in the human body. In the eye, RPE cells
face rod and cone photoreceptor outer segments at all times but contribute to shedding and …

Cell therapies aim to repair the mechanisms underlying disease initiation and progression,
achieved through trophic effect or by cell replacement. Multiple cell types can be utilized in …

Progress in retinal-cell therapy derived from human pluripotent stem cells currently faces
technical challenges that require the development of easy and standardized protocols. Here …

Controlling the differentiation of human pluripotent stem cells is the goal of many
laboratories, both to study normal human development and to generate cells for …

Purpose.: We sought to determine if human induced pluripotent stem cells (iPSCs) derived
from blood could produce optic vesicle–like structures (OVs) with the capacity to stratify and …

Various artificial membranes have been used as scaffolds for retinal pigment epithelium
cells (RPE) for monolayer reconstruction, however, long-term cell viability and functionality …

Despite considerable effort and significant therapeutic advances, age-related macular
degeneration (AMD) remains the commonest cause of blindness in the developed world …

Purpose.: To determine the effects of serial expansion on the cellular, molecular, and
functional properties of human iPS cell (hiPSC)-derived RPE cultures. Methods.: Fibroblasts …

The retinal pigment epithelium contains three major types of pigment granules;
melanosomes, lipofuscin and melanolipofuscin. Melanosomes in the retinal pigment …

Age-related ocular diseases, such as age-related macular degeneration (AMD), diabetic
retinopathy, and glaucoma, result in life-long functional deficits and enormous global health …