Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …

It is now well known that tumor immunosurveillance contributes to the control of cancer
growth. Many mechanisms can be used by cancer cells to avoid the antitumor immune …

A growing body of evidence supports a role for glial-produced neuroimmune factors,
including the cytokine IL-6, in CNS physiology and pathology. CNS expression of IL-6 has …

Synaptic plasticity is fundamental to the neural processes underlying learning and memory.
Interestingly, synaptic plasticity itself can be dynamically regulated by prior activity, in a …

The hallmark of neuroinflammation is the activation of microglia, the immunocompetent cells
of the CNS, releasing a number of proinflammatory mediators implicated in the …

As the largest family of membrane proteins in the human genome, G protein-coupled
receptors (GPCRs) constitute the targets of more than one-third of all modern medicinal …

1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (α-PVP) is a new designer drug of the cathinone
type. People who have taken drugs containing α-PVP or other synthetic cathinone reportedly …

A single, 6 mg/kg intraperitoneal injection of reserpine increased floating time during forced
swim testing 24 h after administration in rats in five experiments. Although such behavioral …

In this paper the authors provide evidence that hydroxyurea (hydroxycarbamide) interacts
with α7 nicotinic acetylcholine receptor, exerts anti-inflammatory and pro-survival effect …

Adenosine (Ado) exerts neuroprotective and anti-inflammatory functions by acting through
four receptor subtypes A 1, A 2A, A 2B and A 3. Astrocytes are one of its targets in the central …