The role of glutathione in protecting against the severe inflammatory response triggered by COVID-19
F Silvagno, A Vernone, GP Pescarmona - Antioxidants, 2020 - mdpi.com
The novel COVID-19 pandemic is affecting the world's population differently: mostly in the
presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal …
presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal …
Glutathione: new roles in redox signaling for an old antioxidant
K Aquilano, S Baldelli, MR Ciriolo - Frontiers in pharmacology, 2014 - frontiersin.org
The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …
past decades superimposing the research on free radicals, oxidative stress and, more …
Oxidative stress during HIV infection: mechanisms and consequences
AV Ivanov, VT Valuev-Elliston… - Oxidative medicine …, 2016 - Wiley Online Library
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …
Pathogen recognition by the innate immune system
Microbial infection initiates complex interactions between the pathogen and the host.
Pathogens express several signature molecules, known as pathogen-associated molecular …
Pathogens express several signature molecules, known as pathogen-associated molecular …
Redox-modulating agents in the treatment of viral infections
P Checconi, M De Angelis, ME Marcocci… - International Journal of …, 2020 - mdpi.com
Viruses use cell machinery to replicate their genome and produce viral proteins. For this
reason, several intracellular factors, including the redox state, might directly or indirectly …
reason, several intracellular factors, including the redox state, might directly or indirectly …
[HTML][HTML] SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione
Viral infections sustain their replication cycle promoting a pro-oxidant environment in the
host cell. In this context, specific alterations of the levels and homeostatic function of the …
host cell. In this context, specific alterations of the levels and homeostatic function of the …
Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications
AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
Infectious agents and neurodegeneration
G De Chiara, ME Marcocci, R Sgarbanti, L Civitelli… - Molecular …, 2012 - Springer
A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …
Glutathione supplementation as an adjunctive therapy in COVID-19
V Guloyan, B Oganesian, N Baghdasaryan, C Yeh… - Antioxidants, 2020 - mdpi.com
Morbidity and mortality of coronavirus disease 2019 (COVID-19) are due in large part to
severe cytokine storm and hypercoagulable state brought on by dysregulated host …
severe cytokine storm and hypercoagulable state brought on by dysregulated host …
Influenza virus down-modulates G6PD expression and activity to induce oxidative stress and promote its replication
M De Angelis, D Amatore, P Checconi… - Frontiers in Cellular …, 2022 - frontiersin.org
Influenza virus infection induces oxidative stress in host cells by decreasing the intracellular
content of glutathione (GSH) and increasing reactive oxygen species (ROS) level. Glucose-6 …
content of glutathione (GSH) and increasing reactive oxygen species (ROS) level. Glucose-6 …