The role of glutathione in protecting against the severe inflammatory response triggered by COVID-19

F Silvagno, A Vernone, GP Pescarmona - Antioxidants, 2020 - mdpi.com
The novel COVID-19 pandemic is affecting the world's population differently: mostly in the
presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal …

Glutathione: new roles in redox signaling for an old antioxidant

K Aquilano, S Baldelli, MR Ciriolo - Frontiers in pharmacology, 2014 - frontiersin.org
The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …

Oxidative stress during HIV infection: mechanisms and consequences

AV Ivanov, VT Valuev-Elliston… - Oxidative medicine …, 2016 - Wiley Online Library
It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …

Pathogen recognition by the innate immune system

H Kumar, T Kawai, S Akira - International reviews of immunology, 2011 - Taylor & Francis
Microbial infection initiates complex interactions between the pathogen and the host.
Pathogens express several signature molecules, known as pathogen-associated molecular …

Redox-modulating agents in the treatment of viral infections

P Checconi, M De Angelis, ME Marcocci… - International Journal of …, 2020 - mdpi.com
Viruses use cell machinery to replicate their genome and produce viral proteins. For this
reason, several intracellular factors, including the redox state, might directly or indirectly …

[HTML][HTML] SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

D Bartolini, AM Stabile, S Bastianelli, D Giustarini… - Redox biology, 2021 - Elsevier
Viral infections sustain their replication cycle promoting a pro-oxidant environment in the
host cell. In this context, specific alterations of the levels and homeostatic function of the …

Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications

AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …

Infectious agents and neurodegeneration

G De Chiara, ME Marcocci, R Sgarbanti, L Civitelli… - Molecular …, 2012 - Springer
A growing body of epidemiologic and experimental data point to chronic bacterial and viral
infections as possible risk factors for neurodegenerative diseases, including Alzheimer's …

Glutathione supplementation as an adjunctive therapy in COVID-19

V Guloyan, B Oganesian, N Baghdasaryan, C Yeh… - Antioxidants, 2020 - mdpi.com
Morbidity and mortality of coronavirus disease 2019 (COVID-19) are due in large part to
severe cytokine storm and hypercoagulable state brought on by dysregulated host …

Influenza virus down-modulates G6PD expression and activity to induce oxidative stress and promote its replication

M De Angelis, D Amatore, P Checconi… - Frontiers in Cellular …, 2022 - frontiersin.org
Influenza virus infection induces oxidative stress in host cells by decreasing the intracellular
content of glutathione (GSH) and increasing reactive oxygen species (ROS) level. Glucose-6 …