Analysis of DNA methylation in cancer: location revisited

A Koch, SC Joosten, Z Feng, TC de Ruijter… - Nature reviews Clinical …, 2018 - nature.com
Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Epigenetic regulation of gene expression in cancer: techniques, resources and analysis

LT Kagohara, GL Stein-O'Brien, D Kelley… - Briefings in …, 2018 - academic.oup.com
Cancer is a complex disease, driven by aberrant activity in numerous signaling pathways in
even individual malignant cells. Epigenetic changes are critical mediators of these functional …

MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data

V Modhukur, T Iljasenko, T Metsalu, K Lokk… - …, 2018 - Future Medicine
Aim: To develop a web tool for survival analysis based on CpG methylation patterns.
Materials & methods: We utilized methylome data from 'The Cancer Genome Atlas' and used …

[PDF][PDF] OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs

J Anaya - PeerJ Computer Science, 2016 - peerj.com
OncoLnc is a tool for interactively exploring survival correlations, and for downloading
clinical data coupled to expression data for mRNAs, miRNAs, or long noncoding RNAs …

MEXPRESS update 2019

A Koch, J Jeschke, W Van Criekinge… - Nucleic acids …, 2019 - academic.oup.com
The recent growth in the number of publicly available cancer omics databases has been
accompanied by the development of various tools that allow researchers to visually explore …

[HTML][HTML] CDKN2A-mediated molecular subtypes characterize the hallmarks of tumor microenvironment and guide precision medicine in triple-negative breast cancer

T Cheng, Y Wu, Z Liu, Y Yu, S Sun, M Guo… - Frontiers in …, 2022 - frontiersin.org
Currently, breast cancer (BRCA) has become the most common cancer in the world, whose
pathological mechanism is complex. Among its subtypes, triple-negative breast cancer …

[HTML][HTML] Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis

Z Song, F Chao, Z Zhuo, Z Ma, W Li, G Chen - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The pathogenic mechanisms of prostate cancer (PCa) remain to be defined. In this study, we
utilized the Robust Rank Aggregation (RRA) method to integrate 10 eligible PCa microarray …

[HTML][HTML] Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma

J Wei, Z Xu, X Chen, X Wang… - Molecular …, 2020 - spandidos-publications.com
The gasdermin (GSDM) superfamily has been demonstrated to consist of several important
molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this …

[HTML][HTML] A pan-cancer analysis of GINS complex subunit 4 to identify its potential role as a biomarker in multiple human cancers

M Usman, MK Okla, HM Asif… - American Journal of …, 2022 - ncbi.nlm.nih.gov
This study was initiated to explore the expression variation, clinical significance, and
biological importance of the GINS complex subunit 4 (GINS4) in different human cancers as …

[HTML][HTML] Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

S Wu, P Liao, L Yan, Q Zhao, Z Xie, J Dong… - BMC gastroenterology, 2021 - Springer
Background MKI67 plays a vital role in the tumour microenvironment (TME) and congenital
immunity. The present work focuses on exploring the prognosis prediction performance of …