Objectives: We performed a systematic review to assess alterations in measures of diffusion
tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in …

There is increasing interest in developing a reliable, affordable and accessible disease
biomarker of Parkinson's disease (PD) to facilitate disease modifying PD-trials. Imaging …

One objective of modern neuroimaging is to identify markers that can aid in diagnosis,
disease progression monitoring and long-term drug impact analysis. In this study, Parkinson …

Background: In the midbrain of patients with Parkinson disease (PD), there is a selective
loss of dopaminergic neurons in the ventrolateral and caudal substantia nigra (SN). In a …

There is a clear need to develop non-invasive markers of substantia nigra progression in
Parkinson's disease. We previously found elevated free-water levels in the substantia nigra …

BACKGROUND AND PURPOSE: Quantitative susceptibility mapping allows overcoming
several nonlocal restrictions of susceptibility-weighted and phase imaging and enables …

This study tested the hypothesis that diffusion tensor imaging can detect alteration in
microscopic integrity of white matter and basal ganglia regions known to be involved in …

Recent magnetic resonance imaging studies suggest an increased transverse relaxation
rate and reduced diffusion tensor imaging fractional anisotropy values in the substantia …

Diffusion tensor imaging (DTI) allows measuring fractional anisotropy and similar
microstructural indices of the brain white matter. Lower than normal fractional anisotropy as …

The substantia nigra contains dopaminergic cells that project to the striatum and are affected
by the neurodegenerative process that appears in Parkinson's disease (PD). For accurate …