Genetics of age-related macular degeneration (AMD)

MM DeAngelis, LA Owen, MA Morrison… - Human molecular …, 2017 - academic.oup.com
Age-related macular degeneration (AMD) is a progressive blinding disease and represents
the leading cause of visual impairment in the aging population. AMD affects central vision …

[HTML][HTML] Animal models of ocular angiogenesis: from development to pathologies

CH Liu, Z Wang, Y Sun, J Chen - The FASEB Journal, 2017 - ncbi.nlm.nih.gov
Pathological angiogenesis in the eye is an important feature in the pathophysiology of many
vision-threatening diseases, including retinopathy of prematurity, diabetic retinopathy, and …

[WITHDRAWN] retinal vasculature in development and diseases

Y Sun, LEH Smith - Annual review of vision science, 2018 - annualreviews.org
This article was withdrawn on October 15, 2020, at the request of the journal editors, with
agreement from the authors, owing to a substantial amount of unattributed or improperly …

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

Y Okunuki, R Mukai, EA Pearsall… - Proceedings of the …, 2018 - National Acad Sciences
Retinal detachment (RD) is a sight-threatening complication common in many highly
prevalent retinal disorders. RD rapidly leads to photoreceptor cell death beginning within 12 …

Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics

T Dudiki, J Meller, G Mahajan, H Liu… - Nature …, 2020 - nature.com
Tissue microarchitecture and mechanics are important in development and pathologies of
the Central Nervous System (CNS); however, their coordinating mechanisms are unclear …

Interpretation of OCT and OCTA images from a histological approach: clinical and experimental implications

N Cuenca, I Ortuno-Lizaran, X Sanchez-Saez… - Progress in retinal and …, 2020 - Elsevier
Optical coherence tomography (OCT) and OCT angiography (OCTA) have been a
technological breakthrough in the diagnosis, treatment, and follow-up of many retinal …

Sirt1: a guardian of the development of diabetic retinopathy

M Mishra, AJ Duraisamy, RA Kowluru - Diabetes, 2018 - Am Diabetes Assoc
Diabetic retinopathy is a multifactorial disease, and the exact mechanism of its pathogenesis
remains obscure. Sirtuin 1 (Sirt1), a multifunctional deacetylase, is implicated in the …

Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia/reperfusion

J Canonica, R Foxton, MG Garrido, CM Lin… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Clinical trials demonstrated that co-targeting angiopoietin-2 (Ang-2) and
vascular endothelial growth factor (VEGF-A) with faricimab controls anatomic outcomes and …

Assessment of Inner Blood–Retinal Barrier: Animal Models and Methods

K Bora, N Kushwah, M Maurya, MC Pavlovich, Z Wang… - Cells, 2023 - mdpi.com
Proper functioning of the neural retina relies on the unique retinal environment regulated by
the blood–retinal barrier (BRB), which restricts the passage of solutes, fluids, and toxic …

Noninvasive delivery of self-regenerating cerium oxide nanoparticles to modulate oxidative stress in the retina

CS Shin, RA Veettil, TS Sakthivel… - ACS Applied Bio …, 2022 - ACS Publications
Diseases affecting the retina, such as age-related macular degeneration (AMD), diabetic
retinopathy, macular edema, and retinal vein occlusions, are currently treated by the …