Proteomics beyond trypsin

L Tsiatsiani, AJR Heck - The FEBS journal, 2015 - Wiley Online Library
Peptide‐centered shotgun analysis of proteins has been the core technology in mass
spectrometry based proteomics and has enabled numerous biological discoveries, such as …

Adenovirus structure: what is new?

J Gallardo, M Pérez-Illana, N Martín-González… - International journal of …, 2021 - mdpi.com
Adenoviruses are large (~ 950 Å) and complex non-enveloped, dsDNA icosahedral viruses.
They have a pseudo-T= 25 triangulation number with at least 12 different proteins …

Six alternative proteases for mass spectrometry–based proteomics beyond trypsin

P Giansanti, L Tsiatsiani, TY Low, AJR Heck - Nature protocols, 2016 - nature.com
Protein digestion using a dedicated protease represents a key element in a typical mass
spectrometry (MS)-based shotgun proteomics experiment. Up to now, digestion has been …

Adenovirus core proteins: structure and function

S Kulanayake, SK Tikoo - Viruses, 2021 - mdpi.com
Adenoviruses have served as a model for investigating viral-cell interactions and
discovering different cellular processes, such as RNA splicing and DNA replication. In …

Application of targeted mass spectrometry in bottom-up proteomics for systems biology research

NP Manes, A Nita-Lazar - Journal of proteomics, 2018 - Elsevier
The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Components of adenovirus genome packaging

YS Ahi, SK Mittal - Frontiers in microbiology, 2016 - frontiersin.org
Adenoviruses (AdVs) are icosahedral viruses with double-stranded DNA (dsDNA) genomes.
Genome packaging in AdV is thought to be similar to that seen in dsDNA containing …

Structure, function and dynamics in adenovirus maturation

WF Mangel, C San Martín - Viruses, 2014 - mdpi.com
Here we review the current knowledge on maturation of adenovirus, a non-enveloped
icosahedral eukaryotic virus. The adenovirus dsDNA genome fills the capsid in complex with …

Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection

VS Reddy, GR Nemerow - Proceedings of the National …, 2014 - National Acad Sciences
Adenovirus cement proteins play crucial roles in virion assembly, disassembly, cell entry,
and infection. Based on a refined crystal structure of the adenovirus virion at 3.8-Å …

The structure of enteric human adenovirus 41—A leading cause of diarrhea in children

K Rafie, A Lenman, J Fuchs, A Rajan, N Arnberg… - Science …, 2021 - science.org
Human adenovirus (HAdV) types F40 and F41 are a prominent cause of diarrhea and
diarrhea-associated mortality in young children worldwide. These enteric HAdVs differ …

Nuclear entry of DNA viruses

N Fay, N Panté - Frontiers in microbiology, 2015 - frontiersin.org
DNA viruses undertake their replication within the cell nucleus, and therefore they must first
deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear …