To thrive and to fulfill their functions, cells need to maintain proteome homeostasis even in
the face of adverse environmental conditions or radical restructuring of the proteome during …

Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …

Heat-shock transcription factor 1 (HSF1) orchestrates the fast and vast cellular response to
heat shock through increased expression of heat-shock proteins. However, how HSF1 …

Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …

For decades, research in cancer biology has been focused on the protein-coding fraction of
the human genome. However, with the discovery of non-coding RNAs (ncRNAs), it has …

Repetitive DNA is a major organizational component of eukaryotic genomes, being
intrinsically related with their architecture and evolution. Tandemly repeated satellite DNAs …

Satellite DNA is characterized by long, tandemly repeated sequences mainly found in
centromeres and pericentromeric chromosomal regions. The recent advent of telomere‐to …

SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here,
we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an …

A substantial portion of the primate genome is composed of non-coding regions, so-called
“dark matter”, which includes an abundance of tandemly repeated sequences called satellite …

Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …