Purpose Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC)
syndrome, with an estimated prevalence of 2% to 3% of CRC. A prevalence study is needed …

Background Hereditary nonpolyposis colorectal cancer HNPCC, Lynch syndrome) is a
genetic disease of autosomal dominant inheritance. It is caused by a mutation in one of four …

Results Clinical criteria are currently available according to which many hereditary cancer
syndromes can be diagnosed or suspected and which point the way to further molecular …

Background Individuals with pathogenic germline variants in DNA mismatch repair (MMR)
genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch …

In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an
instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by …

Purpose: To assess the cost-effectiveness of routine Lynch syndrome (LS) screening among
colorectal cancer (CRC) patients≤ 70 years of age. Methods: A population-based series of …

Lynch syndrome (LS) is one of the inherited colorectal cancer (CRC) syndromes and is due
to germline mutations in one of the mismatch repair (MMR) genes. Within LS affected …

Carriers of mismatch repair (MMR) gene mutations have a high lifetime risk for colorectal
and endometrial cancers, as well as other malignancies. As mutation analysis to detect …

Abstract Human chromosome 8q24. 21 has been implicated as a susceptibility region for
colorectal cancer (CRC) as a result of genome‐wide association and candidate gene …

Background Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant
syndrome. The National Cancer Institute (NCI) has recommended the Revised Bethesda …