Protective responses to microorganisms involve the nonspecific but rapid defence
mechanisms of the innate immune system, followed by the specific but slow defence …

The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Bone marrow-derived B cells make an important cell fate choice to develop into either
follicular B cells or marginal zone B cells in the spleen, which depends on signalling through …

Mice deficient in sphingosine 1-phosphate receptor type 2 (S1P2) develop diffuse large B
cell lymphoma. However, the role of S1P2 in normal germinal center (GC) physiology is …

Rho family GTPases, and the proteins that regulate them, have important roles in many
cellular processes, including cell division, survival, migration and adhesion. Although most …

Plasma cells (PCs) are responsible for the production of protective antibodies against
infectious agents but they also produce pathogenic antibodies in autoimmune diseases …

Hypertension is one of the most frequent pathologies in the industrialized world. Although
recognized to be dependent on a combination of genetic and environmental factors, its …

S1P1 receptor expression is required for the egress of newly formed T cells from the thymus
and exit of mature T and B cells from secondary lymphoid organs. In this study, we deleted …

Spleen marginal zone (MZ) B cells are important for antibody responses against blood-
borne antigens. The signals they use to detect exposure to blood are not well defined. Here …

Accumulating data indicate that G12 subfamily (Gα12/13)-mediated signaling pathways play
pivotal roles in a variety of physiological processes, while aberrant regulation of this …