Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

The inflammasome is a molecular platform formed by activation of an innate immune pattern
recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC …

Background The interleukin-1 (IL-1) mediated systemic autoinflammatory diseases,
including the cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor …

Autoinflammatory diseases are characterised by fever and systemic inflammation, with
potentially serious complications. Owing to the rarity of these diseases, evidence-based …

The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates
the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by …

Objective To evaluate genetic, demographic and clinical features in patients with cryopyrin-
associated periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype …

Objective To examine the synthesis, processing, and secretion of interleukin‐1β (IL‐1β), as
well as the clinical and biologic effects of IL‐1 blockade, in patients with chronic infantile …

Background Cryopyrin-associated periodic syndromes (CAPS) consist of a continuum of
autoinflammatory diseases caused by a defect in interleukin 1β regulation. Although …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

Objective To identify a set of clinical parameters that can predict the probability of carrying
mutations in one of the genes associated with hereditary autoinflammatory syndromes …