There has been considerable recent interest in the genetic, biological and epidemiological
basis of mammographic density (MD), and the search for causative links between MD and …

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …

High mammographic density is the most important risk factor for breast cancer, after ageing.
However, the composition, architecture, and mechanical properties of high X-ray density soft …

Background Elevated mammographic breast density is a strong breast cancer risk factor with
poorly understood etiology. Increased deposition of collagen, one of the main fibrous …

Diagnosis of breast carcinomas has so far been limited to the morphological interpretation of
epithelial cells and the assessment of epithelial tissue architecture. Consequently, most of …

Introduction: Overall survival of early-stage breast cancer patients is similar for those who
undergo breast-conserving therapy (BCT) and mastectomy; however, 10% to 15% of women …

Background High mammographic density has been correlated with a 4-fold to 6-fold
increased risk of developing breast cancer, and is associated with increased stromal …

Introduction Mammographic density is similar among women at risk of either sporadic or
BRCA1/2-related breast cancer. It has been suggested that digitized mammographic images …

Mammographic density refers to the radiological appearance of fibroglandular and adipose
tissue on a mammogram of the breast. Women with relatively high mammographic density …

Sporadic breast cancer develops through the accumulation of molecular abnormalities in
normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning …