Understanding the detailed mechanism behind every human disease, disorder, defect, and
deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Although they are primitive vertebrates, zebrafish (Danio rerio) and medaka (Oryzias latipes)
have surpassed other animals as the most used model organisms based on their many …

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic
and developmental studies. Our understanding of the physiological consequences of altered …

Estrogen-related receptor alpha (ESRRa) regulates a number of cellular processes
including development of bone and muscles. However, direct evidence regarding its …

Zebrafish (Danio rerio) are aquatic vertebrates with significant homology to their terrestrial
counterparts. While zebrafish have a centuries-long track record in developmental and …

Collagens are the most abundant vertebrate extracellular matrix proteins. They form a
superfamily of 28 members that show a remarkable diversity in molecular and …

Abstract pax6 is a canonic master gene for eye formation. Knockout of pax6 affects the
development of craniofacial skeleton and eye in mice. Whether pax6 affects the …

Abstract STAT (Signal Transducers and Activators of Transcription) gene family members
have been revealed to be involved in cell growth and differentiation in vertebrates. Despite …

The last decade has seen an increased interest in the discovery of compounds with bone
anabolic activity to treat skeletal disorders such as osteoporosis and increase the well-being …