[HTML][HTML] Human leukocyte antigen (HLA) and immune regulation: how do classical and non-classical HLA alleles modulate immune response to human …
NB Crux, S Elahi - Frontiers in immunology, 2017 - frontiersin.org
The genetic factors associated with susceptibility or resistance to viral infections are likely to
involve a sophisticated array of immune response. These genetic elements may modulate …
involve a sophisticated array of immune response. These genetic elements may modulate …
[HTML][HTML] Adaptive NK cell response to human cytomegalovirus: facts and open issues
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system.
These include the differentiation and persistent expansion of a mature NK cell subset which …
These include the differentiation and persistent expansion of a mature NK cell subset which …
Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E
SG Hansen, HL Wu, BJ Burwitz, CM Hughes… - Science, 2016 - science.org
Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed,
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …
nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in …
HLA-E–restricted SARS-CoV-2–specific T cells from convalescent COVID-19 patients suppress virus replication despite HLA class Ia down-regulation
H Yang, H Sun, S Brackenridge, X Zhuang… - Science …, 2023 - science.org
Pathogen-specific CD8+ T cell responses restricted by the nonpolymorphic nonclassical
class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections …
class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections …
[HTML][HTML] Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19
Purpose Host genetic variants may contribute to severity of COVID-19. NKG2C+ NK cells are
potent antiviral effector cells, potentially limiting the extent of SARS-CoV-2 infections …
potent antiviral effector cells, potentially limiting the extent of SARS-CoV-2 infections …
Imprint of human cytomegalovirus infection on the NK cell receptor repertoire
M Gumá, A Angulo, C Vilches, N Gómez-Lozano… - Blood, 2004 - ashpublications.org
Expression of the activating CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E
was analyzed in peripheral blood lymphocytes (PBLs) from healthy adult blood donors; the …
was analyzed in peripheral blood lymphocytes (PBLs) from healthy adult blood donors; the …
Intracellular trafficking of HLA-E and its regulation
W He, E Gea-Mallorquí, H Colin-York… - Journal of Experimental …, 2023 - rupress.org
Interest in MHC-E–restricted CD8+ T cell responses has been aroused by the discovery of
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …
their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model …
Class I HLA haplotypes form two schools that educate NK cells in different ways
A Horowitz, Z Djaoud, N Nemat-Gorgani… - Science …, 2016 - science.org
Natural killer (NK) cells are lymphocytes that have vital functions in innate and adaptive
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) …
immunity, as well as placental reproduction. Polymorphic human leukocyte antigen (HLA) …
HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses
Z Lin, AA Bashirova, M Viard, L Garner, M Quastel… - Nature …, 2023 - nature.com
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …
HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A and CD94/NKG2C …
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …