Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in
the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is …

Brain cells are continuously exposed to corticosteroid hormones, although the levels vary
(eg, after stress). Corticosteroids alter neural activity via two receptor types …

Early-life stress lastingly affects adult cognition and increases vulnerability to
psychopathology, but the underlying mechanisms remain elusive. In this Opinion article, we …

Whereas genetic factors contribute crucially to brain function, early-life events, including
stress, exert long-lasting influence on neuronal function. Here, we focus on the …

Childhood traumatic events hamper the development of the hippocampus and impair
declarative memory in susceptible individuals. Persistent elevations of hippocampal …

Advances made in diverse areas of neuroscience suggest that neurotransmitter systems,
additional to the monoaminergic, contribute to the pathophysiology of mood disorders. This …

Stress in adulthood can have a profound effect on physiology and behavior, but the extent to
which prolonged maternal stress affects the brain function of offspring when they are adult …

The administration of dexamethasone, a synthetic glucocorticoid receptor agonist, causes
neuronal death in the CA3 layer of the hippocampus, which has been associated with …

Objective. There is much concern about potential neurodevelopmental impairment after
neonatal corticosteroid treatment for chronic lung disease. Dexamethasone is the …

The NMDA receptor complex represents a key molecular element in the pathogenesis of
long-term synaptic changes and motor abnormalities in Parkinson's disease (PD). Here we …