1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …

The current 'fixed-dosage strategy'approach to medicine, means there is much inter-
individual variation in drug response. Pharmacogenetics is the study of how inter-individual …

The introduction of tacrolimus in clinical practice has improved patient survival after organ
transplant. However, despite the long use of tacrolimus in clinical practice, the best way to …

ABSTRACT MDR1 is an ATP-dependent transmembrane transporter primarily studied for its
role in the detoxification of tissues and for its implication in resistance of tumor cells to …

Genetic factors contribute to the phenotype of drug response, but the translation of
pharmacogenetic outcomes into drug discovery, drug development or clinical practice has …

Tacrolimus trough and dose requirements vary dramatically between individuals of
European and African American ancestry. These differences are less well described in other …

Purpose In children, data on the combined impact of age, genotype, and disease severity on
tacrolimus (TAC) disposition are scarce. The aim of this study was to evaluate the effect of …

What is known and objectives Tacrolimus (TAC) is widely used as part of
immunosuppressive regimens. There is great interindividual variation on the disposition of …

Abstract Background: Tacrolimus (Tac) is an immunosuppressive drug used to prevent post-
transplant (PT) organ rejection. Continuous Tac monitoring is necessary to adjust the dose …

BACKGROUND: The published data revealed conflicting results of the polymorphism of
MDR1 exon 26 SNP C3435T on the pharmacokinetics of tacrolimus in different post …