The role of inflammation and the gut microbiome in depression and anxiety
JM Peirce, K Alviña - Journal of neuroscience research, 2019 - Wiley Online Library
The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …
brain function and mental health. In this review, we underscore specific pathways and …
TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
Abstract Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is
required for TLR-mediated production of type-I IFN and several other proinflammatory …
required for TLR-mediated production of type-I IFN and several other proinflammatory …
'Layered immunity'and the 'neonatal window of opportunity'–timed succession of non‐redundant phases to establish mucosal host–microbial homeostasis after birth
MW Hornef, N Torow - Immunology, 2020 - Wiley Online Library
The intricate host–microbial interaction and the overwhelming complexity of the mucosal
immune system in the adult host raise the question of how this system is initially established …
immune system in the adult host raise the question of how this system is initially established …
Gut microbiota-derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice
D Bajic, A Niemann, AK Hillmer… - Journal of Crohn's …, 2020 - academic.oup.com
Abstract Background and Aims Regenerating islet-derived protein type 3 [Reg3] lectins are
antimicrobial peptides at mucosal surfaces of the gut, whose expression is regulated by …
antimicrobial peptides at mucosal surfaces of the gut, whose expression is regulated by …
From birth to death: The hardworking life of Paneth cell in the small intestine
C Cui, F Wang, Y Zheng, H Wei, J Peng - Frontiers in Immunology, 2023 - frontiersin.org
Paneth cells are a group of unique intestinal epithelial cells, and they play an important role
in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as …
in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as …
The intestinal epithelium as guardian of gut barrier integrity
K Zhang, MW Hornef, A Dupont - Cellular microbiology, 2015 - Wiley Online Library
A single layer of epithelial cells separates the intestinal lumen from the underlying sterile
tissue. It is exposed to a multitude of nutrients and a large number of commensal bacteria …
tissue. It is exposed to a multitude of nutrients and a large number of commensal bacteria …
Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium
JA Van Winkle, ST Peterson, EA Kennedy… - elife, 2022 - elifesciences.org
Abstract Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric
viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that …
viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that …
Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish
PP Jia, M Junaid, PP Wen, YF Yang, WG Li… - Environmental …, 2021 - Elsevier
Numerous pieces of evidence documented the importance of gut microbiota in regulating
human health and evaluating the toxicity of environmental pollutants, which are closely …
human health and evaluating the toxicity of environmental pollutants, which are closely …
TLR signaling modulates side effects of anticancer therapy in the small intestine
M Frank, EM Hennenberg, A Eyking… - The Journal of …, 2015 - journals.aai.org
Intestinal mucositis represents the most common complication of intensive chemotherapy,
which has a severe adverse impact on quality of life of cancer patients. However, the precise …
which has a severe adverse impact on quality of life of cancer patients. However, the precise …
Paneth cells during viral infection and pathogenesis
MK Holly, JG Smith - Viruses, 2018 - mdpi.com
Paneth cells are major secretory cells located in the crypts of Lieberkühn in the small
intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and …
intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and …