The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …

Abstract Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is
required for TLR-mediated production of type-I IFN and several other proinflammatory …

The intricate host–microbial interaction and the overwhelming complexity of the mucosal
immune system in the adult host raise the question of how this system is initially established …

Abstract Background and Aims Regenerating islet-derived protein type 3 [Reg3] lectins are
antimicrobial peptides at mucosal surfaces of the gut, whose expression is regulated by …

Paneth cells are a group of unique intestinal epithelial cells, and they play an important role
in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as …

A single layer of epithelial cells separates the intestinal lumen from the underlying sterile
tissue. It is exposed to a multitude of nutrients and a large number of commensal bacteria …

Abstract Interferon-lambda (IFN-λ) protects intestinal epithelial cells (IECs) from enteric
viruses by inducing expression of antiviral IFN-stimulated genes (ISGs). Here, we find that …

Numerous pieces of evidence documented the importance of gut microbiota in regulating
human health and evaluating the toxicity of environmental pollutants, which are closely …

Intestinal mucositis represents the most common complication of intensive chemotherapy,
which has a severe adverse impact on quality of life of cancer patients. However, the precise …

Paneth cells are major secretory cells located in the crypts of Lieberkühn in the small
intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and …