[HTML][HTML] Precision medicine in human heart modeling: perspectives, challenges, and opportunities
Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …
Patient-specific modeling of dyssynchronous heart failure: a case study
J Aguado-Sierra, A Krishnamurthy, C Villongco… - Progress in biophysics …, 2011 - Elsevier
The development and clinical use of patient-specific models of the heart is now a feasible
goal. Models have the potential to aid in diagnosis and support decision-making in clinical …
goal. Models have the potential to aid in diagnosis and support decision-making in clinical …
[HTML][HTML] The living heart project: a robust and integrative simulator for human heart function
B Baillargeon, N Rebelo, DD Fox, RL Taylor… - European Journal of …, 2014 - Elsevier
The heart is not only our most vital, but also our most complex organ: Precisely controlled by
the interplay of electrical and mechanical fields, it consists of four chambers and four valves …
the interplay of electrical and mechanical fields, it consists of four chambers and four valves …
Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery
S Sankaran, M Esmaily Moghadam, AM Kahn… - Annals of biomedical …, 2012 - Springer
We present a computational framework for multiscale modeling and simulation of blood flow
in coronary artery bypass graft (CABG) patients. Using this framework, only CT and non …
in coronary artery bypass graft (CABG) patients. Using this framework, only CT and non …
Patient-specific models of cardiac biomechanics
A Krishnamurthy, CT Villongco, J Chuang… - Journal of computational …, 2013 - Elsevier
Patient-specific models of cardiac function have the potential to improve diagnosis and
management of heart disease by integrating medical images with heterogeneous clinical …
management of heart disease by integrating medical images with heterogeneous clinical …
Theoretical impact of the injection of material into the myocardium: a finite element model simulation
Background—To treat cardiac injuries created by myocardial infarcts, current approaches
seek to add cells and/or synthetic extracellular matrices to the damaged ventricle to restore …
seek to add cells and/or synthetic extracellular matrices to the damaged ventricle to restore …
Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation
In this study we present a novel, robust method to couple finite element (FE) models of
cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac …
cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac …
[HTML][HTML] Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium
The pericardium affects cardiac motion by limiting epicardial displacement normal to the
surface. In computational studies, it is important for the model to replicate realistic motion, as …
surface. In computational studies, it is important for the model to replicate realistic motion, as …
Bioenergetic and functional consequences of bone marrow–derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling
L Zeng, Q Hu, X Wang, A Mansoor, J Lee, J Feygin… - Circulation, 2007 - Am Heart Assoc
Background—The present study examined whether transplantation of adherent bone
marrow–derived stem cells, termed pMultistem, induces neovascularization and …
marrow–derived stem cells, termed pMultistem, induces neovascularization and …
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments
Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …
place in the human heart, including ventricular remodeling, which is frequently associated …