Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda… - … Reviews Molecular Cell …, 2022 - nature.com
Human topoisomerases comprise a family of six enzymes: two type IB (TOP1 and
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
mitochondrial TOP1 (TOP1MT), two type IIA (TOP2A and TOP2B) and two type IA (TOP3A …
Untangling the roles of TOP2A and TOP2B in transcription and cancer
L Uusküla-Reimand, MD Wilson - Science advances, 2022 - science.org
Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …
reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic …
Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
catenanes and enable chromosome segregation. Human cells encode six topoisomerases …
Genome organization drives chromosome fragility
In this study, we show that evolutionarily conserved chromosome loop anchors bound by
CCCTC-binding factor (CTCF) and cohesin are vulnerable to DNA double strand breaks …
CCCTC-binding factor (CTCF) and cohesin are vulnerable to DNA double strand breaks …
Anthracyclines as topoisomerase II poisons: from early studies to new perspectives
J Marinello, M Delcuratolo, G Capranico - International journal of …, 2018 - mdpi.com
Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by
stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to …
stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to …
Drugging topoisomerases: lessons and challenges
Y Pommier - ACS chemical biology, 2013 - ACS Publications
Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements.
They are essential during transcription and replication, and topoisomerase inhibitors are …
They are essential during transcription and replication, and topoisomerase inhibitors are …
Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity
Topoisomerase II (TOP2) relieves torsional stress by forming transient cleavage complex
intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are …
intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are …
New mechanistic and functional insights into DNA topoisomerases
SH Chen, NL Chan, T Hsieh - Annual review of biochemistry, 2013 - annualreviews.org
DNA topoisomerases are nature's tools for resolving the unique problems of DNA
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
entanglement that occur owing to unwinding and rewinding of the DNA helix during …
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Abstract Background Type II DNA topoisomerases (TOP2) regulate DNA topology by
generating transient double stranded breaks during replication and transcription …
generating transient double stranded breaks during replication and transcription …
Spatial chromosome folding and active transcription drive DNA fragility and formation of oncogenic MLL translocations
HJ Gothe, BAM Bouwman, EG Gusmao, R Piccinno… - Molecular cell, 2019 - cell.com
How spatial chromosome organization influences genome integrity is still poorly understood.
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …
Here, we show that DNA double-strand breaks (DSBs) mediated by topoisomerase 2 (TOP2) …