Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …

Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma.
The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal
permselectivity of glomerular basement membrane (GBM) plays an important role in DN …

Heparanase has regulatory roles in various processes, including cell communication, gene
transcription and autophagy. In addition, it is the only known mammalian endoglycosidase …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated
with colon cancer. Expression of the enzyme heparanase is clearly linked to colon …

Heparan sulfate (HS) proteoglycans at the cell surface and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and are implicated in disease …

• Heparan sulphate proteoglycans‐Heparan sulphate‐Heparan sulphate interactions‐Core
proteins• Heparanase‐Molecular properties of human heparanase‐1‐Working mechanism …