[HTML][HTML] VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment
Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …
Despite developments in therapeutic approaches for the past few decades, the 5-year …
Recent advances in the mechanisms and treatment of immune thrombocytopenia
Primary immune thrombocytopenia is an autoimmune disease associated with a reduced
peripheral blood platelet count. The phenotype is variable with some patients suffering no …
peripheral blood platelet count. The phenotype is variable with some patients suffering no …
[HTML][HTML] Anti-rheumatoid drugs advancements: New insights into the molecular treatment of rheumatoid arthritis
RB Mrid, N Bouchmaa, H Ainani, R El Fatimy… - Biomedicine & …, 2022 - Elsevier
Rheumatoid arthritis (RA) is one of more than 100 types of arthritis. This chronic autoimmune
disorder affects the lining of synovial joints in about 0.5% of people and may induce severe …
disorder affects the lining of synovial joints in about 0.5% of people and may induce severe …
m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …
[HTML][HTML] Short chain fatty acids, a possible treatment option for autoimmune diseases
Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty
acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play …
acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play …
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells
O Morante-Palacios, G Godoy-Tena… - Nucleic acids …, 2022 - academic.oup.com
Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective
activation of naïve T cells. DCs' immunological properties are modulated in response to …
activation of naïve T cells. DCs' immunological properties are modulated in response to …
Bispecific antibody targeting TGF-β and PD-L1 for synergistic cancer immunotherapy
T Li, X Wang, M Niu, M Wang, J Zhou, K Wu… - Frontiers in …, 2023 - frontiersin.org
The PD-1/PD-L1 signaling pathway plays a crucial role in cancer immune evasion, and the
use of anti-PD-1/PD-L1 antibodies represents a significant milestone in cancer …
use of anti-PD-1/PD-L1 antibodies represents a significant milestone in cancer …
Metabolic programming in dendritic cells tailors immune responses and homeostasis
SH Møller, L Wang, PC Ho - Cellular & molecular immunology, 2022 - nature.com
It is being increasingly acknowledged that immune cells depend on certain metabolic traits
to perform their functions and that the extracellular environment can influence cell …
to perform their functions and that the extracellular environment can influence cell …
[HTML][HTML] Application of dendritic cells in tumor immunotherapy and progress in the mechanism of anti-tumor effect of Astragalus polysaccharide (APS) modulating …
D Wang, Q Cui, YJ Yang, AQ Liu, G Zhang… - Biomedicine & …, 2022 - Elsevier
Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that are essential in
mediating the body's natural and adaptive immune responses. The body can regulate the …
mediating the body's natural and adaptive immune responses. The body can regulate the …
Tolerogenic dendritic cell-based approaches in autoimmunity
L Passeri, F Marta, V Bassi, S Gregori - International journal of molecular …, 2021 - mdpi.com
Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. In the
context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including …
context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including …