Intestinal epithelial cells: regulators of barrier function and immune homeostasis
LW Peterson, D Artis - Nature reviews immunology, 2014 - nature.com
The abundance of innate and adaptive immune cells that reside together with trillions of
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …
[HTML][HTML] Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology
Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in
combination with prebiotics,(indigestible dietary fibre/carbohydrate), also confer a health …
combination with prebiotics,(indigestible dietary fibre/carbohydrate), also confer a health …
[HTML][HTML] A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns
Signaling by Toll-like receptors (TLRs) on intestinal epithelial cells (IECs) is critical for
intestinal homeostasis. To visualize epithelial expression of individual TLRs in vivo, we …
intestinal homeostasis. To visualize epithelial expression of individual TLRs in vivo, we …
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
MT Abreu - Nature reviews immunology, 2010 - nature.com
A single layer of epithelial cells lines the small and large intestines and functions as a barrier
between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) …
between commensal bacteria and the rest of the body. Ligation of Toll-like receptors (TLRs) …
[HTML][HTML] Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?
GL Hold, M Smith, C Grange, ER Watt… - World journal of …, 2014 - ncbi.nlm.nih.gov
Our understanding of the microbial involvement in inflammatory bowel disease (IBD)
pathogenesis has increased exponentially over the past decade. The development of newer …
pathogenesis has increased exponentially over the past decade. The development of newer …
[HTML][HTML] Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity
EM Eshleman, TY Shao, V Woo, T Rice… - The Journal of …, 2023 - Am Soc Clin Investig
Aberrant immune responses to resident microbes promote inflammatory bowel disease and
other chronic inflammatory conditions. However, how microbiota-specific immunity is …
other chronic inflammatory conditions. However, how microbiota-specific immunity is …
Principles and clinical implications of the brain–gut–enteric microbiota axis
SH Rhee, C Pothoulakis, EA Mayer - Nature reviews Gastroenterology & …, 2009 - nature.com
While bidirectional brain–gut interactions are well known mechanisms for the regulation of
gut function in both healthy and diseased states, a role of the enteric flora—including both …
gut function in both healthy and diseased states, a role of the enteric flora—including both …
[PDF][PDF] The intestinal barrier function and its involvement in digestive disease
E Salvo Romero, C Alonso Cotoner… - Rev Esp Enferm …, 2015 - online.reed.es
The gastrointestinal mucosal surface is lined with epithelial cells representing an effective
barrier made up with intercellular junctions that separate the inner and the outer …
barrier made up with intercellular junctions that separate the inner and the outer …
Inflammatory bowel disease: cause and immunobiology
DC Baumgart, SR Carding - The Lancet, 2007 - thelancet.com
Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …
[HTML][HTML] Toll-like receptors: regulators of the immune response in the human gut
H Hug, MH Mohajeri, G La Fata - Nutrients, 2018 - mdpi.com
Toll-like receptors (TLRs) are powerful molecular regulators by which the immune system
may “sense” the environment and protect the host from pathogens or endogenous threats. In …
may “sense” the environment and protect the host from pathogens or endogenous threats. In …