A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead
was replaced by a 1, 3, 4-oxadiazole or 1, 3, 4-thiadiazole moiety, was efficiently …

Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate, and the survival
rate of HCC patients remains low. Animal medicines have been used as potential …

Docetaxel is a first-line chemotherapy drug used to treat advanced prostate cancer, but
patients who have used it often face the challenges of drug resistance and side effects …

Aaptamine (8, 9-dimethoxy-1H-benzo [de][1, 6] naphthyridine), an alkaloid obtained from
marine sponges of the genus Aaptos (Demospongiae, Suberitida, Suberitidae), has …

Background. Preeclampsia (PE) is a common obstetric disorder hallmarked by impaired
trophoblast invasion and a skew toward an inflammatory immune response. Echinatin, a …

Asymmetric synthesis is key in the construction of complex natural products, many of which
possess chiral centers. Xestospongin compounds are chiral, medicinally intriguing …