This review summarizes the state-of-art in liquid chromatography–mass spectrometry (LC–
MS) and related techniques with the main focus on recent developments in the last decade …

Sensitive and specific methods for the detection, characterization and quantification of
endogenous steroids in body fluids or tissues are necessary for the diagnosis, pathological …

Multiple hydroxy‐, keto‐, di‐, and tri‐carboxylic acids are among the cellular metabolites of
central carbon metabolism (CCM). Sensitive and reliable analysis of these carboxylates is …

The inclusion of preliminary chemical labeling (derivatization) in the analysis process by
such powerful and widespread methods as electrospray ionization (ESI) and matrix-assisted …

The determination of steroids in biological samples is essential in different areas of
knowledge. MS combined with either GC or LC is considered the best analytical technique …

Gas chromatography (GC) and liquid chromatography (LC) coupled to mass spectrometric
(MS) detection have become the two main techniques for the analysis of metabolite pools (ie …

Trace amines (TAs) are metabolically related to catecholamine and associated with cancer
and neurological disorders. Comprehensive measurement of TAs is essential for …

Liquid chromatography–mass spectrometry (LC–MS) is considered today as a mainstay tool
for the structure characterization of minor components like impurities (IMPs) and degradation …

Derivatization, or chemical structure modification, is often used in bioanalysis performed by
liquid chromatography technique in order to enhance detectability or to improve the …

Urine is a biological matrix that contains hundreds of metabolic end products which
constitute the urinary metabolome. The development and advances on LC–MS/MS have …