Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

The therapeutic armamentarium of acute myeloid leukemia (AML) has rapidly expanded in
the past few years, driven largely by translational research into its genomic landscape and …

Myeloid malignancies, including acute myeloid leukaemia (AML), arise from the expansion
of haematopoietic stem and progenitor cells that acquire somatic mutations. Bulk molecular …

Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection.
Precise characterization of clonal architecture is essential to understand the evolutionary …

A current challenge in cancer treatment is drug resistance. Even the most effective therapies
often fail to produce a complete and durable tumor response and ultimately give rise to …

Recent advances in cellular profiling have demonstrated substantial heterogeneity in the
behaviour of cells once deemed'identical', challenging fundamental notions of …

Individual cell heterogeneity within a population can be critical to its peculiar function and
fate. Subpopulations studies with mixed mutants and wild types may not be as informative …

To enable the characterization of genetic heterogeneity in tumor cell populations, we
developed a novel microfluidic approach that barcodes amplified genomic DNA from …

Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …

The prognosis of most patients with AML is poor due to frequent disease relapse. The cause
of relapse is thought to be from the persistence of leukemia initiating cells (LIC's) following …