Global chemical analysis of biology by mass spectrometry

AA Aksenov, R da Silva, R Knight, NP Lopes… - Nature Reviews …, 2017 - nature.com
Mass spectrometry instruments measure the mass to charge ratio of ions, from which we
infer the molecular structures. They are key tools for investigating the incredibly diverse …

OMERO: flexible, model-driven data management for experimental biology

C Allan, JM Burel, J Moore, C Blackburn, M Linkert… - Nature …, 2012 - nature.com
Data-intensive research depends on tools that manage multidimensional, heterogeneous
datasets. We built OME Remote Objects (OMERO), a software platform that enables access …

Cooler: scalable storage for Hi-C data and other genomically labeled arrays

N Abdennur, LA Mirny - Bioinformatics, 2020 - academic.oup.com
Motivation Most existing coverage-based (epi) genomic datasets are one-dimensional, but
newer technologies probing interactions (physical, genetic, etc.) produce quantitative maps …

Phenotypic image analysis software tools for exploring and understanding big image data from cell-based assays

K Smith, F Piccinini, T Balassa, K Koos, T Danka… - Cell systems, 2018 - cell.com
Phenotypic image analysis is the task of recognizing variations in cell properties using
microscopic image data. These variations, produced through a complex web of interactions …

Scientific data exchange: a schema for HDF5-based storage of raw and analyzed data

F De Carlo, D Gürsoy, F Marone, M Rivers… - Journal of synchrotron …, 2014 - scripts.iucr.org
Data Exchange is a simple data model designed to interface, orexchange', data among
different instruments, and to enable sharing of data analysis tools. Data Exchange focuses …

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment

S Wink, S Hiemstra, S Huppelschoten… - Chemical research in …, 2014 - ACS Publications
Over the past decade, major leaps forward have been made on the mechanistic
understanding and identification of adaptive stress response landscapes underlying toxic …

An IFC schema extension and binary serialization format to efficiently integrate point cloud data into building models

T Krijnen, J Beetz - Advanced Engineering Informatics, 2017 - Elsevier
In this paper we suggest an extension to the Industry Foundation Classes (IFC) model to
integrate point cloud datasets. The proposal includes a schema extension to the core model …

Draw: a new data-grouping-aware data placement scheme for data intensive applications with interest locality

J Wang, P Shang, J Yin - Cloud Computing for Data-Intensive Applications, 2014 - Springer
Recent years have seen an increasing number of scientists employ data parallel computing
frameworks such as MapReduce and Hadoop to run data intensive applications and …

Adaptive informatics for multifactorial and high-content biological data

BL Millard, M Niepel, MP Menden, JL Muhlich… - Nature …, 2011 - nature.com
Whereas genomic data are universally machine-readable, data from imaging, multiplex
biochemistry, flow cytometry and other cell-and tissue-based assays usually reside in …

mz5: space-and time-efficient storage of mass spectrometry data sets

M Wilhelm, M Kirchner, JAJ Steen, H Steen - Molecular & Cellular …, 2012 - ASBMB
Across a host of MS-driven-omics fields, researchers witness the acquisition of ever
increasing amounts of high throughput MS data and face the need for their compact yet …