Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Molecular alterations in genes involved in DNA mismatch repair (MMR) promote cancer
initiation and foster tumour progression. Cancers deficient in MMR frequently show …

Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but
there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

There is a surge in demand for safe and targeted therapy against cancer as the conventional
treatment approach fails to reach the specific site. Chemotherapeutic agents are generally …

Simple Summary This review depicts the principal mechanisms involved in the process of
stromal desmoplasia characterizing pancreatic ductal adenocarcinoma (PDAC). The aim of …