The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

Methods for the targeted disruption of protein function have revolutionized science and
greatly expedited the systematic characterization of genes. Two main approaches are …

More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

During pathogen infection, antibodies can be carried into the infected cell, where they are
detected by the ubiquitously expressed cytosolic antibody receptor TRIM21. Here we found …

Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor
that provides a last line of defense against invading viruses. It does so by acting as a sensor …

Protein depletion is a key approach to understanding the functions of a protein in a
biological system. We recently developed the Trim-Away approach in order to rapidly …

Human adenoviruses are the most widely used vectors in gene medicine, with applications
ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side …

Alzheimer's disease (AD) and other neurodegenerative disorders are associated with the
cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports …

The Golgi apparatus is a central intracellular membrane-bound organelle with key functions
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …